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Legend Biotech Stock: A Battle for Momentum Amid Mixed Signals

Robert Sasse by Robert Sasse
November 3, 2025
in Analysis, Pharma & Biotech, Turnaround
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Legend Biotech Corp finds itself at a critical juncture, navigating a complex landscape of promising clinical developments against a backdrop of regulatory challenges and financial headwinds. The cell therapy specialist’s path forward remains uncertain as it attempts to reconcile these conflicting signals and establish sustainable recovery.

Financial Performance Presents Contrasting Picture

The company’s most recent quarterly results reveal a tale of two narratives. On one hand, Legend Biotech demonstrated impressive revenue growth, with sales climbing 36.8% year-over-year to reach $255 million, exceeding market expectations. However, this positive development was tempered by a larger-than-anticipated loss per share of $0.34. The company’s profitability challenges are further highlighted by its negative return on equity of 32%, underscoring ongoing financial pressures despite revenue expansion.

Regulatory Setback Clouds Outlook

Early October delivered a significant blow to the biotechnology firm when the U.S. Food and Drug Administration issued a “Boxed Warning” for its flagship product CARVYKTI®. This represents the agency’s most serious warning level, highlighting potentially life-threatening side effects associated with the cancer treatment. For a company heavily dependent on its approved therapies, such regulatory restrictions pose substantial threats to commercial success and market confidence.

Institutional Investors Display Divergent Strategies

Major financial institutions appear deeply divided on Legend Biotech’s prospects. Recent activity reveals starkly contrasting approaches among professional investors. While iA Global Asset Management reduced its stake by 16.7% during the second quarter, other institutional players demonstrated remarkable confidence. GAMma Investing LLC boosted its position by an impressive 145.4%, and Brooklyn Investment Group increased its holdings by more than 1,100%. These opposing moves reflect the uncertainty surrounding the company’s mixed outlook.

Should investors sell immediately? Or is it worth buying Legend Biotech Corp?

Analyst Sentiment Maintains Cautious Stance

Despite recent challenges, many market researchers maintain generally positive assessments, though with adjusted expectations. JPMorgan revised its price target downward from $78 to $76 while keeping its “Overweight” rating intact. Similarly, HC Wainwright adjusted its target more significantly from $75 to $60 but continues to recommend the stock as a buy. The current average price target stands at $66.56, suggesting substantial potential upside from the present trading level of approximately €29 per share.

Upcoming Catalysts Offer Potential Turning Points

Several near-term developments could provide the catalyst Legend Biotech needs to regain momentum. The company plans to present new data for CARVYKTI® and its experimental therapy Lucar-G39D at the upcoming ASH annual meeting in December. Positive clinical updates from this presentation could deliver the necessary impetus for share price recovery. Additionally, the quarterly earnings report scheduled for November 12 represents another potential inflection point for investors seeking clarity on the company’s direction.

Following a challenging year that has left the stock trading significantly lower, recent trading patterns indicate initial signs of stabilization. Whether the forthcoming clinical data and financial results can catalyze the much-anticipated turnaround remains the central question facing current and prospective investors.

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Robert Sasse

Robert Sasse

About Dr. Robert Sasse Accomplished economist, entrepreneur, and profound expert in financial markets. Dr. Robert Sasse holds a doctorate in economics and combines academic rigor with practical entrepreneurial experience. His deep expertise in economic relationships and unwavering conviction for a free-market liberal economic order drives his mission to provide investors with well-founded knowledge and guidance.
Areas of Expertise:
  • Economic Theory and Practice
  • Free-Market Economics
  • Entrepreneurship and Business Strategy
  • Investment Philosophy
Dr. Sasse's unique combination of academic knowledge and real-world business experience enables him to provide investors with comprehensive insights that bridge theory and practice.

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